@cyberdyne_skynet I wouldn't expect UI mods to have any impact.
For SIM mods, I'm not (as yet) aware of a mod that M28 is incompatible with (in that it breaks M28 if its used), while M28 should also make use of custom units for most unit mods, and ought to also make use of custom ACU upgrades e.g. from BlackOps where the default upgrades are overwritten (but I last tested this pre-v1 release).
However due to the difficulty in figuring out the cause of issues where there are lots of mods (e.g. it may not even be M28 that is the cause, but an interaction between those two mods, and it could just be that M28 makes such an interaction more likely) my focus would be on games with just 1 other SIM mod where M28 is crashing/suffering major issues.