NVidia released a new driver (466.11) on April 14 which they claim fixes the supcom stuttering issue:
[Supreme Commander/Supreme Commander 2]: The games experience low FPS. [3231218/
3230880]
http://us.download.nvidia.com/Windows/466.11/466.11-win10-win8-win7-release-notes.pdf
However we are getting mixed reports from players about its effectiveness.
If you upgrade the driver and turn off the ui fix mod, do you still get an issue?
Don't forget:
Laticlave has helpfully made a UI mod titled "Nvidia fix" to correct the driver issue until we can get a proper patch out. Feel free to download it from the vault!