I have 3080 card and although i dont play much, i just had a game vs the AI on dual screen and it was unplayable. everytime i moved the mouse the thing jerked all over. Same when i went single screen mode - with my second monitor just windows. I disabled my second monitor from the windows/display setup and then the game runs fine.
I have the latest nvidia driver (466.11) and tried both with and without the nvidia UI fix mod (it made no help to me at all).
Hope this info might help you confirm what you suspect