@xsdna I have been going back and forth with nvidia since I made this post. They may have come up with something that seems to alleviate the issue.
My main monitor was set to perform scaling on my GPU and my second was set to do it on the Display itself. I have checked the "Override the scaling mode set by games and programs" setting and set the second monitor to scale on the GPU. It appears to have solved the issue. I still get a slightly larger frame drop zooming in/out and moving the mouse frantically - but we're talking a 10 fps drop not a 100+ one.
Can you do the same and confirm this? The setting is in the NVIDIA Control Panel under Display, Adjust desktop size and position and then the scaling tab for all of your monitors.